骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)
Multiplex Assay Kit for Osteocalcin (OC) ,etc. by FLIA (Flow Luminescence Immunoassay)
BGLAP; OT; BGP; Bone Gla Protein; Bone Gamma-Carboxyglutamate Protein; Gamma-carboxyglutamic acid-containing protein
（注：單次混測多因子不超過8個指標(biāo) ）
- 編號LMA471Hu
- 物種Homo sapiens (Human，人)相同的名稱，不同的物種。
- 實驗方法雙抗夾心
- 反應(yīng)時長3.5h
- 檢測范圍0.04-40ng/mL
- 靈敏度最小可檢測劑量小于等于0.013 ng/mL.
- 樣本類型Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
- 下載英文說明書 中文說明書
- 規(guī)格8指標(biāo)數(shù)7指標(biāo)數(shù)6指標(biāo)數(shù)5指標(biāo)數(shù)4指標(biāo)數(shù)3指標(biāo)數(shù)2指標(biāo)數(shù)1指標(biāo)數(shù)
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)
通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
特異性
本試劑盒用于檢測骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)，經(jīng)檢測與其它相似物質(zhì)無明顯交叉反應(yīng)。
由于受到技術(shù)及樣本來源的限制，不可能完成對所有相關(guān)或相似物質(zhì)交叉反應(yīng)檢測，因此本試劑盒有可能與未經(jīng)檢測的其它物質(zhì)有交叉反應(yīng)。
回收率
分別于定值血清及血漿樣本中加入一定量的骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)（加標(biāo)樣品），重復(fù)測定并計算其均值，回收率為測定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 96-105 | 99 |
| EDTA plasma(n=5) | 98-105 | 102 |
| heparin plasma(n=5) | 84-92 | 89 |
| sodium citrate plasma(n=5) | 98-105 | 101 |
精密度
精密度用樣品測定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內(nèi)差：取同批次試劑盒對低、中、高值定值樣本進(jìn)行定量檢測,每份樣本連續(xù)測定20 次，分別計算不同濃度樣本的平均值及SD值。
批間差：選取3個不同批次的試劑盒分別對低、中、高值定值樣本進(jìn)行定量測定，每個樣本使用同一試劑盒重復(fù)測定8次，分別計算不同濃度樣本的平均值及SD值。
批內(nèi)差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內(nèi)加入適量的骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)，并倍比稀釋成1:2，1:4，1:8，1:16的待測樣本，線性范圍即為稀釋后樣本中骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)含量的測定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 97-104% | 92-104% | 92-101% | 87-101% |
| EDTA plasma(n=5) | 85-92% | 93-101% | 80-91% | 89-96% |
| heparin plasma(n=5) | 88-99% | 80-97% | 82-97% | 85-101% |
| sodium citrate plasma(n=5) | 94-103% | 85-94% | 89-99% | 98-105% |
穩(wěn)定性
經(jīng)測定，試劑盒在有效期內(nèi)按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對試劑盒破壞前后檢測值的影響，實驗室的環(huán)境條件需盡量保持一致，尤其是實驗室內(nèi)溫度、濕度及溫育條件。其次由同一實驗員來進(jìn)行操作可減少人為誤差。
實驗流程
1. 實驗前標(biāo)準(zhǔn)品、試劑及樣本準(zhǔn)備；
2. 加樣（標(biāo)準(zhǔn)品、樣本、磁珠）標(biāo)準(zhǔn)品或樣本100μL及磁珠10μL，
37°C酶標(biāo)板振蕩器孵育90分鐘；
3. 磁吸甩干，加檢測溶液A100μL，37°C酶標(biāo)板振蕩器孵育60分鐘；
4. 磁吸洗板3次；
5. 加檢測溶液B100μL，37°C振動孵育30分鐘；
6. 磁吸洗板3次；
7. 加鞘液100μL，旋渦震蕩2分鐘后讀數(shù)。
實驗原理
將骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)抗體包被于磁珠，制成固相載體，向微孔中分別加入標(biāo)準(zhǔn)品或標(biāo)本以及磁珠，其中的骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)與連接于固相載體上的抗體結(jié)合，然后加入生物素化的骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)抗體，將未結(jié)合的生物素化抗體洗凈后，加入PE標(biāo)記的親和素，再次徹底洗滌后即可上機(jī)讀數(shù)。MFI值和樣品中的骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法)呈正相關(guān)。
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| 編號 | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| RPA471Hu01 | 骨鈣素(OC)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA471Hu02 | 骨鈣素(OC)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPA471Hu21 | 骨鈣素(OC)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA471Hu22 | 骨鈣素(OC)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA471Hu23 | 骨鈣素(OC)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| CPA471Hu31 | 骨鈣素(OC)鑰孔血藍(lán)蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| PAA471Hu02 | 骨鈣素(OC)多克隆抗體 | WB; IHC; ICC; IP. |
| PAA471Hu01 | 骨鈣素(OC)多克隆抗體 | WB; IHC; ICC; IP. |
| PAA471Hu08 | 骨鈣素(OC)多克隆抗體 | WB; IHC; ICC; IP. |
| MAA471Hu24 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu25 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu27 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu29 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu26 | 骨鈣素(OC)單克隆抗體 | WB; IHC; ICC; IP. |
| MAA471Hu28 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu21 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu23 | 骨鈣素(OC)單克隆抗體 | IHC |
| MAA471Hu22 | 骨鈣素(OC)單克隆抗體 | WB,IHC |
| SEA471Hu | 骨鈣素(OC)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEA471Hu | 骨鈣素(OC)檢測試劑盒(酶聯(lián)免疫吸附試驗法,高敏型) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA471Hu | 骨鈣素(OC)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| KSA471Hu01 | 骨鈣素(OC)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗法) | Main materials for "Do It (ELISA Kit) Yourself". |
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| Toxicology and applied pharmacology | Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways[Pubmed: 31051157] |
| Journal of Innovations in Pharmaceutical and Biological Sciences | Preventive effect of dried plum extract against dexamethasone-induced osteoporosis in male rats through inhibiting cathepsin-K activity, lipogenesis and?…[] |
| JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | A dual functional bone‐defect‐filling material with sequential antibacterial and osteoinductive properties for infected bone defect repair[Pubmed: 31173657] |
| Polymers | Use of Polyphenol Tannic Acid to Functionalize Titanium with Strontium for Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Activity[Pubmed: 31362449] |
| Bulletin of Experimental Biology and Medicine | Laboratory Monitoring of Bone Tissue Remodeling after Augmentation of Impression Intraarticular Fracture with Different Types of Bone Graft[Pubmed: 31630302] |
| International Journal of Nanomedicine | Nano-Hydroxyapatite Coating Promotes Porous Calcium Phosphate Ceramic-Induced Osteogenesis Via BMP/Smad Signaling Pathway[Pubmed: 31632013] |
| Molecular Therapy-Nucleic Acids | AAV-anti-miR-214 prevents collapse of the femoral head in osteonecrosis by regulating osteoblast and osteoclast activities[Pubmed: 31739209] |
| International Journal of Environmental Research and Public Health | Alleviating Effect of α-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats[Pubmed: 31739465] |
| Pharmacology | MiR-296 Promotes Osteoblast Differentiation by Upregulating Cbfal[Pubmed: 31694033] |
| Brazilian Journal of Medical and Biological Research | Beneficial effects of Cuscuta chinensis extract on glucocorticoid-induced osteoporosis through modulation of RANKL/OPG signals[Pubmed: 31826180] |
| Biomedicine & Pharmacotherapy | Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss[Pubmed: 31846839] |
| Journal of Bone and Mineral Research | BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling[Pubmed: 31914211] |
| Theranostics | EDTA-Modified 17β-Estradiol-Laden Upconversion Nanocomposite for Bone-Targeted Hormone Replacement Therapy for Osteoporosis[Pubmed: 32194868] |
| Journal of Korean Neurosurgical Society | Rutin Improves Bone Histomorphometric Values by Reduction of Osteoclastic Activity in Osteoporosis Mouse Model Induced by Bilateral Ovariectomy[Pubmed: 32172552] |
| JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | Positive role of calcium phosphate ceramics regulated inflammation in the osteogenic differentiation of mesenchymal stem cells[Pubmed: 32064734] |
| CELL BIOCHEMISTRY AND FUNCTION | HSP90 inhibitors strengthen extracellular ATP‐stimulated synthesis of interleukin‐6 in osteoblasts: Amplification of p38 MAP kinase[Pubmed: 32567086] |
| Cell Death & Disease | QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism[Pubmed: 32382069] |
| Molecular Medicine Reports | Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3?E1 cells via an autocrine mechanism[Pubmed: 33000198] |
| Food & Function | Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the?…[Pubmed: 33140795] |
| ADVANCED FUNCTIONAL MATERIALS | A Hierarchical Janus Nanofibrous Membrane Combining Direct Osteogenesis and Osteoimmunomodulatory Functions for Advanced Bone Regeneration[] |
| Revista Argentina de Clínica Psicológica | Research on the Mechanism of miR-142-5p's Promotion of the Function and Mineralization of Osteoblasts by Down-regulating the Expression of WWP1 Gene[] |
| 淫羊藿水提物及提取藥渣的抗骨質(zhì)疏松藥效比較研究[] | |
| Chemical Engineering Journal | Bioinspired polydopamine/graphene oxide/collagen nanofilms as a controlled release carrier of bioactive substances[] |
| Surfaces and Interfaces | In vitro comparison of titanium surface conditioning via boron-compounds and sand-blasting acid-etching[] |
| J Bone Miner Res | Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/|??\catenin pathway[33950533] |
| Biochemical Engineering Journal | Studies of osteoblast-like MG-63 cellular proliferation and differentiation with cyclic stretching cell culture system on biomimetic hydrophilic layers modified polydimethylsiloxane substrate[] |
| Br J Pharmacol | Andrographolide prevents bone loss via targeting ERRalpha‐regulated metabolic adaption of osteoclastogenesis[34233019] |
| PHARMACEUTICAL BIOLOGY | Effects of icariin on the fracture healing in young and old rats and its mechanism[34511043] |
| Evid Based Complement Alternat Med | Gujiansan Ameliorates Avascular Necrosis of the Femoral Head by Regulating Autophagy via the HIF-1α/BNIP3 Pathway[34512780] |
| ACS Appl Mater Interfaces | Spatiotemporal Management of the Osteoimmunomodulation of Fibrous Scaffolds by Loading a Novel Amphiphilic Nanomedicine[Pubmed:35311248] |
| Molecules | Notoginsenoside R1 Promotes Migration, Adhesin, Spreading, and Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stromal Cells[Pubmed:35684342] |
| Journal of Exercise Science & Fitness | Effects of 8-week High-Intensity Interval Training and Moderate-Intensity Continuous Training on Bone Metabolism in Sedentary Young Females[Pubmed:35096081] |
| Journal of Bionic Engineering | Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing[] |