轉化生長因子β1(TGFb1)檢測試劑盒(酶聯(lián)免疫吸附試驗法)
ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1)
TGF-B1; CED; DPD1; LAP; Camurati-Engelmann Disease; Latency-associated peptide
- 編號SEA124Gu
- 物種Cavia (Guinea pig ，豚鼠)相同的名稱，不同的物種。
- 實驗方法雙抗夾心
- 反應時長3h
- 檢測范圍0.156-10ng/mL
- 靈敏度最小可檢測劑量小于等于0.054ng/mL.
- 樣本類型serum, platelet-poor plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
- 下載英文說明書 中文說明書
- 規(guī)格48T96T96T*596T*1096T*100
- 價格¥ 3024¥ 4320¥ 19440¥ 36720¥ 302400
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)
實驗結果圖
標準曲線圖
通過ISO 9001、ISO 13485質量體系認證
特異性
本試劑盒用于檢測轉化生長因子β1(TGFb1)，經(jīng)檢測與其它相似物質無明顯交叉反應。
由于受到技術及樣本來源的限制，不可能完成對所有相關或相似物質交叉反應檢測，因此本試劑盒有可能與未經(jīng)檢測的其它物質有交叉反應。
回收率
分別于定值血清及血漿樣本中加入一定量的轉化生長因子β1(TGFb1)（加標樣品），重復測定并計算其均值，回收率為測定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 99-105 | 102 |
| EDTA plasma(n=5) | 78-94 | 84 |
| heparin plasma(n=5) | 92-104 | 97 |
精密度
精密度用樣品測定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內差：取同批次試劑盒對低、中、高值定值樣本進行定量檢測,每份樣本連續(xù)測定20 次，分別計算不同濃度樣本的平均值及SD值。
批間差：選取3個不同批次的試劑盒分別對低、中、高值定值樣本進行定量測定，每個樣本使用同一試劑盒重復測定8次，分別計算不同濃度樣本的平均值及SD值。
批內差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內加入適量的轉化生長因子β1(TGFb1)，并倍比稀釋成1:2，1:4，1:8，1:16的待測樣本，線性范圍即為稀釋后樣本中轉化生長因子β1(TGFb1)含量的測定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 85-97% | 80-99% | 80-94% | 89-103% |
| EDTA plasma(n=5) | 88-96% | 96-104% | 78-89% | 79-93% |
| heparin plasma(n=5) | 82-104% | 85-96% | 93-103% | 96-105% |
穩(wěn)定性
經(jīng)測定，試劑盒在有效期內按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對試劑盒破壞前后檢測值的影響，實驗室的環(huán)境條件需盡量保持一致，尤其是實驗室內溫度、濕度及溫育條件。其次由同一實驗員來進行操作可減少人為誤差。
實驗流程
1. 實驗前標準品、試劑及樣本的準備；
2. 加樣（標準品及樣本）100µL，37°C孵育1小時；
3. 吸棄，加檢測溶液A100µL，37°C孵育1小時；
4. 洗板3次；
5. 加檢測溶液B100µL，37°C孵育30分鐘；
6. 洗板5次；
7. 加TMB底物90µL，37°C孵育10-20分鐘；
8. 加終止液50µL，立即450nm讀數(shù)。
實驗原理
將轉化生長因子β1(TGFb1)抗體包被于96孔微孔板中，制成固相載體，向微孔中分別加入標準品或標本，其中的轉化生長因子β1(TGFb1)與連接于固相載體上的抗體結合，然后加入生物素化的轉化生長因子β1(TGFb1)抗體，將未結合的生物素化抗體洗凈后，加入HRP標記的親和素，再次徹底洗滌后加入TMB底物顯色。TMB在過氧化物酶的催化下轉化成藍色，并在酸的作用下轉化成最終的黃色。顏色的深淺和樣品中的轉化生長因子β1(TGFb1)呈正相關。用酶標儀在450nm波長下測定吸光度(O.D.值)，計算樣品濃度。
增值服務
相關產(chǎn)品
| 編號 | 適用物種：Cavia (Guinea pig ，豚鼠) | 應用(僅供研究使用，不用于臨床診斷！) |
| RPA124Gu01 | 轉化生長因子β1(TGFb1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAA124Gu01 | 轉化生長因子β1(TGFb1)多克隆抗體 | WB; IHC; ICC; IP. |
| LAA124Gu71 | 轉化生長因子β1(TGFb1)多克隆抗體(生物素標記) | WB; IHC; ICC. |
| LAA124Gu81 | 轉化生長因子β1(TGFb1)多克隆抗體(異硫氰酸熒光素標記) | WB; IHC; ICC; IF. |
| MAA124Gu21 | 轉化生長因子β1(TGFb1)單克隆抗體 | WB; IHC; ICC; IP. |
| SEA124Gu | 轉化生長因子β1(TGFb1)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA124Gu | 轉化生長因子β1(TGFb1)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
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| EUROPEAN JOURNAL OF PHARMACOLOGY | The anti-asthmatic potential of flavonol kaempferol in an experimental model of allergic airway inflammation[Pubmed: 33122672] |
| Journal of Cosmetic Dermatology | Examination of androgenetic alopecia with serum biomarkers[Pubmed: 32969583] |
| MOLECULAR AND CELLULAR BIOCHEMISTRY | Soluble recombinant human thrombomodulin suppresses inflammation-induced gastrointestinal tumor growth in a murine peritonitis model[Pubmed: 32767229] |
| CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | Hepatoprotective effect of Linagliptin against liver fibrosis induced by carbon tetrachloride in mice[Pubmed: 32726558] |
| EXPERIMENTAL DERMATOLOGY | Decreased suppression of CD8+ and CD4+ T cells by peripheral Regulatory T cells in Generalized Vitiligo due to reduced NFATC1 and FOXP3 proteins[Pubmed: 32682346] |
| Scientific Reports | Erlotinib can halt adenine induced nephrotoxicity in mice through modulating ERK1/2, STAT3, p53 and apoptotic pathways[Pubmed: 32661331] |
| international journal of biological macromolecules | Chlorella vulgaris α-L-arabino-α-L-rhamno-α, β-D-galactan structure and mechanisms of its anti-inflammatory and anti-remodelling effects[Pubmed: 32565301] |
| Exp Cell Res | Exosomal miR-532–5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5[Pubmed: 32464126] |
| JOURNAL OF IMMUNOLOGY RESEARCH | The Sufficient Immunoregulatory Effect of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with …[Pubmed: 32411794] |
| Frontiers in Pharmacology | M10, a Myricetin-3-ObD-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice[Pubmed: 33041798] |
| Food & Function | Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial?…[] |
| Effect of metformin and indole-3-carbinol on a rat model of Parkinson's disease induced by 6-hydroxydopamine[] | |
| Research square | Vitamin D Status in Dupuytren's Disease: Association with Clinical Status and Vitamin D Receptor Expression[] |
| Phytomedicine | Menthacarin attenuates experimental colitis[] |
| Immunomodulatory effects of sCD83 via induction of TGF-β1 and IDO: an in vitro and rat orthotopic liver transplantation study[] | |
| BMC Complement Med Ther | Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma[33413331] |
| Life Sci | Celecoxib ameliorates liver cirrhosis via reducing inflammation and oxidative stress along spleen-liver axis in rats[33577848] |
| CLINICAL SCIENCE | Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes[33491733] |
| Bioact Mater | New design to remove leukocytes from platelet-rich plasma (PRP) based on cell dimension rather than density[33842739] |
| Acta Biomater | Highly interconnected inverse opal extracellular matrix scaffolds enhance stem cell therapy in limb ischemia[33878473] |
| Mol Cell Biochem | Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in??-[33864569] |
| Cell Death & Disease | Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization[34006822] |
| PLoS One | Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment?aIn vivo studies[33999928] |
| Vascular pharmacology | Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE1 axis[33945869] |
| Equine Vet J | Limited added value of negative pressure wound therapy compared to calcium alginate dressings for second intention healing in a non?\contaminated and??-[34115409] |
| Stem Cells International | The Paracrine Effect of Adipose-Derived Stem Cells Orchestrates Competition between Different Damaged Dermal Fibroblasts to Repair UVB-Induced Skin??-[33381190] |
| Journal of Pharmacy and Pharmacology | Pharmacodynamic evaluation of dihydroxyflavone derivate chrysin in a guinea pig model of allergic asthma[33793800] |
| Bull. Egypt. Soc. Physiol. Sci. | Flaxseed Oil Supplementation Afford Comparable Therapeutic effect to Metformin in Bleomycin Induced Pulmonary Fibrosis Rat model[] |
| D￡?ˉ | Role of Angiotensin II and Renal Nerves on TGF-b/SmadPathway in Diabetic Nephropathy Rat Model[] |
| Bioactive Materials | Calcium phosphate-based materials regulate osteoclast-mediated osseointegration[] |
| Mediators of Inflammation | Sparstolonin B Exerts Therapeutic Effects on Collagen-Induced Arthritis by Inhibiting the NLRP3 Inflammasome and Reducing the Activity of |á1, 3 ?-[] |
| Manuscript title Microparticles Containing MiR-625-5p In Coronary Artery Reduce Myocardial Fibrosis After Myocardial Infarction[] | |
| Andrology | X‐ray micro‐computed tomography in the assessment of penile cavernous fibrosis in a rabbit castration model[34236146] |
| Aging | Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular?…[34315133] |
| Tissue Eng Regen Med | Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method[34339025] |
| Am J Transl Res | Wuling San and Xiao Chaihu Decoction affect airway inflammatory response and airway smooth muscle cell proliferation in mice with allergic asthma via miR?…[34786062] |
| Biomacromolecules | In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration[34723499] |
| Brain Sci | Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial?…[34942919] |
| Biomedicines | Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes[34829910] |
| J Inflamm Res | Clenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice[Pubmed:35058704] |
| Cancer Commun (Lond) | Anti‐PD‐L1/TGF‐βR fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer[Pubmed:34981670] |
| Polymers (Basel) | 3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-β1 Nanoparticles Mimicking the Growth Factor Footprint of Human Bone Tissue[Pubmed:35267680] |
| Biomed Pharmacother | Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis[Pubmed:35453007] |
| Biomed Pharmacother | Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats[Pubmed:35430394] |
| Antioxidants | Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant's Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory?…[Pubmed:35204215] |
| Frontiers in Molecular Neuroscience | Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines[Pubmed:35465093] |
| Vaccines | Age-Dependent Dynamics of Maternally Derived Antibodies (MDAs) and Understanding MDA-Mediated Immune Tolerance in Foot-and-Mouth Disease-Vaccinated?…[Pubmed:35632433] |
| Biomaterials Advances | Human adipose-derived stem cell-loaded small intestinal submucosa as a bioactive wound dressing for the treatment of diabetic wounds in rats[] |
